TECDOC - 1223 Current status of neutron capture therapy
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10B Concentration, Phantom Size and Tumor Location Dependent Dose Enhancement and Neutron Spectra in Boron Neutron Capture Therapy
Background: The amount of average dose enhancement in tumor loaded with 10B may vary due to various factors in boron neutron capture therapy.Objective: This study aims to evaluate dose enhancement in tumor loaded with 10B under influence of various factors and investigate the dependence of this dose enhancement on neutron spectra changes.Material and Methods: In this simulation stud...
متن کاملAn Introduction to Boron Neutron Therapy (BNCT): Current Status and Future Outlook
Boron neutron capture therapy (BNCT) is based on the nuclear reaction, such that B-10 irradiated with low-energy thermal neutrons produces alpha particles with high linear energy transfer and lithium-7. Clinically, BNCT is used primarily for treatment of high-grade glioma or brain metastases from melanoma and, more recently, head, neck and liver cancers. Since reactors have long been used to pr...
متن کاملAn investigation into the potential applicability of gel dosimeters for dosimetry in boron neutron capture therapy
Background: The aim of this work was to establish how well gel dosimeters performed, as substitutes for brain tissue compared with standard phantom materials such as water, polymethyl-methacrylate (or PMMA), A150 plastic and TE- liquid phantom material for dosimetry of neutron beams in boron neutron capture therapy. Materials and Methods: Thermal neutron fluence, photon dose and epithermal neu...
متن کاملDesign and Simulation of Photoneutron Source by MCNPX Monte Carlo Code for Boron Neutron Capture Therapy
Introduction Electron linear accelerator (LINAC) can be used for neutron production in Boron Neutron Capture Therapy (BNCT). BNCT is an external radiotherapeutic method for the treatment of some cancers. In this study, Varian 2300 C/D LINAC was simulated as an electron accelerator-based photoneutron source to provide a suitable neutron flux for BNCT. Materials and Methods Photoneutron sources w...
متن کاملInvestigation the potential of Boron neutron capture therapy (BNCT) to treat the lung cancer
Introduction: Boron neutron capture therapy (BNCT) is recommended to treat the glioblastoma tumor. It is well known that neuron beams are more effective treatment than photon beams to treat hypoxia tumors due to interaction of neutron with nucleus and production of heavy particles such as 7Li and alpha particle. In this study to evaluate the suitability of BNCT for treating of ...
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